Molecular Studies of Important Species of Astragalus L. (Fabaceae) ab 59.99 € als Taschenbuch: Molecular systematics of Astragalus rhizanthus complex. Aus dem Bereich: Bücher, Wissenschaft, Biologie,
Liver is crucial to health and life. Liver cell death is a cardinal feature of almost every prevalent liver disease. Ethanol-induced cell death by necrosis and/or apoptosis is a valid model to test for hepatoprotective agents. Potential approaches include amino acids and phytochemicals. The pharmacologic effects of glycine (Gly), cysteine, N-acetylcysteine, Astragalus spinosus and Astragalus boeticus (A. boeticus) were investigated on hepatocyte death. Agents with cytoprotective effects were further examined by estimating reduced glutathione, lipid peroxidation and membrane blebbing. Moreover, the molecular mechanisms underlying Gly hepatoprotection were studied using isolated rat hepatocytes. Caspase-3 activity, chromatin condensation and cytochrome c translocation were assessed. In conclusion, both Gly and A. boeticus demonstrated promising hepatoprotective effects. Particularly, Gly could be a very effective drug to ameliorate liver injuries because it prevents both forms of hepatocyte death. This study should be especially useful to pharmacologists, clinical hepatologists, nutritionists, and to every liver patient who might benefit one day from this experimental research.
With about 3000 species worldwide, Astragalus is considered as most diverse and polymorphic genus of the family Leguminosae (Fabaceae) divided into eight to ten subgenera and more than 245 sections. It is chiefly distributed in temperate and alpine zones of Himalayas. Some species are the source of commercial gum tragacanth however, some are medicinally important used in treatment of cancer, HIV infection, tumors of eyes, liver, throat, chest and back pain in US, china and India. Few species have been reported poisonous for both livestock (cattle & sheep) as it contains Nitrotoxin, Swainsonine and Selenium.